I organize the games I want into thus: OMFG GET IT NOW!!!111" and "its an afterthought. get it when the price drops."
on the OMFG one, there are three for this year, and 4 for next year.
OMFG:
Batman: Arkham Asylum (pre-ordered and ready to play as The Joker on Launch Day.
Marvel Ultimate Alliance 2
Fallout 3 GOTY edition
God of War 3
Fallout: New Vegas
Dead Rising 2
Afterthoughts:
Ghostbusters
Brutal Legend
Dead Space
Infamous
Prototype
and a few others.
I'm not feeling too excited by a whole lot this gen. which is why, beyond those 2 categories up there, I'm working tirelessly to work on my massive last-gen collection.